<- Home <- Arhive <- Vol. 26, Issue 1, March 2018



Rom J Leg Med26(1)67-69(2018)
DOI:10.4323/rjlm.2018.67
© Romanian Society of Legal Medicine


Medicolegal implications of an autopsy case of hypothermia under the influence of flunitrazepam and quetiapine

H. Kinoshita, N. Tanaka, A. Takakura, M. Kumihashi, M. Jamal, A. Ito, K. Tsutsui, S. Kimura, K. Ameno


Abstract: Toxicological examination is an integral part of determining cause of death but must be considered in conjunction with other autopsy findings and the results of the investigation of the victim’s surroundings. We present a fatal case involving a victim who had ingested flunitrazepam and quetiapine. Quantitative toxicological analysis revealed that the concentrations of 7-aminoflunitrazepam (a metabolite of flunitrazepam) and quetiapine in a femoral blood sample were 0.46 μg/mL and 0.48 μg/mL, respectively. However, her cardiac blood oxygen saturation met the criteria for hypothermia. These pathophysiological findings strongly suggested that the forensic diagnosis for her cause of death was hypothermia, rather than the direct effects of the drug as measured on toxicological analysis. From the autopsy findings, results of the toxicological examination, and investigation by the authorities, we concluded that the cause of death was hypothermia under the influence of flunitrazepam and quetiapine.
Keywords: flunitrazepam, quetiapine, hypothermia, oxygen saturation, cardiac blood.



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