THE ROLE OF NGF IN THE REGENERATION OF PERIPHERAL NERVE INJURY – SYSTEMATIC REVIEW – IMPLICATIONS FOR THE PROVISION OF DAYS OF MEDICAL CARE AFTER PERIPHERAL NERVE INJURIES

O. C. Sciboz, M. A. Paun, M. Popescu, L. Stănciulescu, I. Lascar

Abstract: The peripheral nervous system has a great repair capacity after injury but the regeneration after peripheral nerve injury is often unsatisfactory [1]. Depending on the size of the defect, these lesions may be treated with primary repair, nerve transplantation or nerve transfer [2].
The clinical results show poor function deficits even if the micro-surgical suture is done in the best conditions [3].
Several adjuvant strategies to repair are currently being developed to speed up the recovery of nerve conduction. The neuronal growth factor is one of the growth factors that could affect nerve regeneration [4].
The aim of this work is a systematic review of the literature on the effects of neuronal growth factor (NGF) as an adjunct to peripheral nerve regeneration.
The speeding up of the healing process after traumatic injuries leads to the modification of the healing and recovery period with the reducing time of medical care with implications in forensic medicine.
Keywords: peripheral nerve regeneration, neuronal growth factor, NGF, nerve recovery.