S. Furukawa, A. Takaya, T. Nakagawa, I. Sakaguchi, K. Nishi
Abstract: Melanosis coli is described as a black or brown discoloration of the mucosa of the colon. It is a benign
condition arising from laxative abuse and has no symptoms of its own. Representative autopsy appearances of melanosis coli are
shown where the deceased took antiobesity drugs. Melanosis coli is most often detected during examinations for long-standing
constipation, often in conjunction with a history of the chronic use of anthracene cathartics. This case report is intended to
remind the clinicians that extensive melanosis coli may mimic ischemic colitis and thus must be considered as a differential
diagnosis. Keywords: melanosis coli, antiobesity drugs, rhubarb
